The Galderma aesthetics range, RESTYLANE and Restylane Refyne - The science behind fillers and treatments

DESIGNED DIFFERENTLY

Often imitated, never matched. Restylane® is a collection of hyaluronic acid fillers and skin quality hyaluronic acid injectables that range from the firmest filler in the market to the most soft and flexible.1–5 Discover the advantages of choosing products from Restylane® and what makes them different.

EXPERIENCE THE RESTYLANE® DIFFERENCE

More than just volumizing. Restylane® offers from shaping and structural support, to natural expression, to a healthy glow treatment solutions.1–4,6,7

 

Our hyaluronic acid works in sync with your skin for 100% natural-looking results.8–10 Trusted by healthcare professionals for 3 decades, we provide state-of-the-art education for optimal injection safety and the best treatment outcomes.11–13

 

Achieve the look you want on your own terms – small tweaks or dramatic changes, how you define your look is entirely up to you.

The Galderma aesthetics range, RESTYLANE and Restylane Refyne - Why people want to refine facial features

Less is more

With Restylane® you can achieve optimal results with less filler gel compared with other hyaluronic acid injectables.8,14,15

 

Avoid looking “done”

Are you concerned that your facial expressions, like your smiles and laughs, will look unnatural after a filler treatment? With Restylane® there’s no need to worry. Restylane® DEFYNE™ and Restylane® REFYNE™ have both been proven to maintain natural facial expressions after treatment.9,16–19

 

Less worry about puffiness 

For some treatments, avoiding puffiness is essential, not least when treating the under-eye area.20–22 Restylane® EYELIGHT™, Restylane® and Restylane® LYFT™ have all been proven to have less water uptake compared with competitor brands.22–27

 

Precise and predictable

Restylane® offers fillers with meticulously researched properties, allowing injectors to select the ideal product for achieving the desired outcome.1–4,6,28 Learn more about gel technologies below.

Restylane Diff

UNIQUE TECHNOLOGIES

Restylane® fillers are based on 4 innovative technologies that are meaningfully designed to mimic the diverse range of facial structures and skin layers to go beyond volumizing.1–4,29,30 This makes it possible to achieve highly customized outcomes that suit individual preferences for 100% natural-looking results.1,6,8,9

 

 

NASHA HD™ From lower face shaping
NASHA HD™ technology is our new shaper technology, used to create the appearance of enhanced bone structure.4,31

 

Restylane® SHAYPE™ is our first NASHA HD™ filler, providing a bone-mimicking effect for shaping the chin.4,31,32

 

 

NASHA™ To structural support
NASHA™ technology is used to create a range of firm fillers designed for lift, projection and structure.2,3,6,10,33

 

NASHA™ fillers are Restylane®, Restylane® EYELIGHT™ and Restylane® LYFT™.2,3,25–27,34

 

 

OBT™ To natural expressions
OBT™ technology is used to produce fillers that are soft and flexible.2,3,6 They integrate seamlessly with the tissue to move with natural facial expressions,3,10,33 such as when we laugh, smile or blow a kiss.9,16,17,35

 

OBT™ fillers are Restylane® KYSSE™, Restylane® VOLYME™, Restylane® DEFYNE™ and Restylane® REFYNE™.2,3,18,19,36,37 They are used on dynamic areas of the face, such as the cheeks and lips.2,3,6

 

These fillers are the only hyaluronic acid fillers in the market that have been clinically proven to move naturally when tested on real patients.9,16,17,38*

 

 

SB NASHA™ To a healthy glow
SB NASHA™ technology is used to produce skin quality injectables that continuously optimize the extracellular matrix by promoting native hyaluronic acid, elastin and collagen production and optimize cell renewal to visibly improve 6 key signs of skin quality for up to 15 months.30,39–44

 

SB NASHA™ skin quality injectables are Skinboosters Vital and Skinboosters Vital Light.3,30,39,45,46

A complimentary range

THE HISTORY OF HYALURONIC ACID DERMAL FILLERS

When Restylane® was launched more than 27 years ago, it was the world’s first non-animal dermal filler with stabilized hyaluronic acid.11,47 Before, hyaluronic acid gels were of animal origin, with the associated higher risks of causing unwanted immune reactions.47–49

 

Hyaluronic acid is a native molecule that occurs naturally in our bodies.49,50 It is a polysaccharide, a kind of sugar molecule, which can bind huge amounts of water – 1,000 times its own weight.49–53 Hyaluronic acid therefore helps our bodies to retain water and to keep our body tissues soft, hydrated and flexible.51–56

 

Restylane® uses a customized hyaluronic acid that is the closest to skin’s own.47,50,57,58 This pure, high-molecular-weight hyaluronic acid mimics what is naturally present in our skin to ensure patients are getting the optimal treatment outcome.3,47,58–60
 

The history

100%

“The overall appearance of my face looks natural”9

96.7%

“My face looks natural when it’s relaxed”9

93.3%

“My face looks natural when I’m smiling”9

References

  1. Metelitsa A et al. J Cosmet Dermatol. 23(5):1604–12.
  2. Öhrlund A et al. J Drugs Dermatol. 2024;23(1):1332–6.
  3. Rogerio V et al. J Stomatol Oral Maxillofac Surg. 2022;123(4):440–7.
  4. Nikolis A et al. J Drugs Dermatol. 2024;23(4):255–61.
  5. Galderma. Data on file. MA-56724. 2023.
  6. Di Gregorio C et al. Clin Cosmet Investig Dermatol. 2022;14:681–90.
  7. Dierickx C et al. Dermatol Surg. 2018;44 Suppl. 1:S10–8.
  8. Hilton S et al. Dermatol Surg. 2018;44(2):261–9.
  9. Solish N et al. J Cosmet Dermatol. 2019;18(3):738–46.
  10. Lundgren B et al. J Drugs Dermatol. 2018;17(9):982–6.
  11. Galderma. Data on file. MA-57232. 2023.
  12. Nikolis A et al. Clin Cosmet Investig Dermatol. 2024;17:2051–69.
  13. Galderma. Annual Review 2023. Available at: https://galderma.com/annual-review-2023 (accessed November 2024).
  14. Weiss R et al. Dermatol Surg. 2021;47(4):527–32.
  15. Jones D et al. J Drugs Dermatol. 2021;20(9):949–56.
  16. Percec I et al. Plast Reconstr Surg. 2020;145:295e–305e.
  17. Philipp-Dormston WG et al. Dermatol Surg. 2018;44(6):826–32.
  18. Restylane Defyne IFU (EU).
  19. Restylane Refyne IFU (EU).
  20. Sharad J. J Cutan Aesthet Surg. 2012;5(4):229–38.
  21. Rohrich J et al. Plast Reconstr Surg Glob Open. 2019;7(6):e2172.
  22. de la Guardia C, et al. Facial Plast Surg. 2022;38(2):116–23.
  23. Fagien S et al. Plast Reconstr Surg. 2019;143(4):707e–20e.
  24. Öhrlund A. Water uptake of hyaluronic acid fillers. Presented at the 23rd IMCAS, Paris, France, 2022.
  25. Restylane Eyelight IFU (EU).
  26. Restylane IFU (EU).
  27. Restylane Lyft IFU (EU).
  28. Öhrlund A. J Cosmet Dermatol. 2018;8:47–54.
  29. Nikolis A, Enright KM. J Dermatol Sci. 2020:2(1):6–8.
  30. Landau M, Fagien S. Plast Reconstr Surg. 2015;136(5 Suppl.):188S–95S.
  31. Nikolis A et al. Effectiveness and Safety of a New NASHA-HD Hyaluronic Acid Injectable, HASHA, for Augmentation and Correction of Chin Retrusion. Presented at the 25th IMCAS, Paris, France. 2024.
  32. Restylane Shaype IFU. IFU-0103.
  33. Nikolis A et al. Aesthet Surg J Open Forum. 2020;2:ojaa005.
  34. Biesmen BS et al. Aesthet Surg J. 2024;44(9):1001–13.
  35. Bertucci V et al. J Cosmet Dermatol. 2021;20(5):1499–504.
  36. Restylane Volyme IFU (EU).
  37. Restylane Kysse IFU (EU).
  38. Philipp-Dormston WG et al. J Cosmet Dermatol. 2020;19(7):1600–6.
  39. Belmontesi M et al. J Drugs Dermatol. 2018;17(1):83–8.
  40. Hsieh DM et al. Aesthet Surg J. 2023;43(5):595–608.
  41. Peng JH, Peng PHL. Indian J Plast Surg. 2020;53(2):198–206.
  42. Avantaggiato A et al. Aesthetic Plast Surg. 2015;39(4):459–64.
  43. Wu Y et al. J Cosmet Dermatol. 2020;19(7):1627–35.
  44. Galderma. Data on File. MA-54615. 2022.
  45. Restylane Vital IFU (EU).
  46. Restylane Vital Light IFU (EU).
  47. Seo K. Volumizing Fillers. In: Facial Volumization with Fillers. Springer, Singapore. 2021;29–83.
  48. Fundaro SP et al. Int J Mol Sci. 2022;23(18):10518.
  49. Greene JJ, Sidle DM. Facial Plast Surg Clin North Am. 2015;23(4):423–32.
  50. Kablik J et al. Dermatol Surg. 2009;35(Suppl. 1):302–12.
  51. Lierova A et al. Pharmaceutics. 2022;14(4):838.
  52. Fallacara A et al. Polymers (Basel). 2018;10(7):701.
  53. Salih ARC et al. Futur J Pharm Sci. 2024;10:63.
  54. Allen J, Dodou K. Cosmetics. 2024;11(2):54.
  55. Pratt RL. Int J Mol Sci. 2021;22(13):6845.
  56. Dovedytis M et al. Eng Regen. 2020;1:102–13.
  57. Edsman K et al. Dermatol Surg. 2012;38(7 Pt. 2):1170–9.
  58. Galderma. Data on file. MA-58650. 2023.
  59. Sadeghpour M et al. Dermatol Surg. 2019;45(8):1085–94.
  60. Heitmiller K et al. J Cosmet Dermatol. 2021;20:28–34.

Always consult your healthcare professional for individualized treatment recommendations and to discuss important safety information and risks associated with the use of the products.

 

* Based on publication analyses that demonstrate no other hyaluronic acid filler product has conducted or published such in vivo studies, as of November 2024.