To fill lines and wrinkles, try Restylane® and Restylane® Refyne™
Restylane and Restylane Refyne are dermal fillers that provide long-lasting reduction of lines and wrinkles, such as nasolabial folds (smile lines) and marionette lines (laugh lines).¹ With Restylane and Restylane Refyne you get tailored and natural results that leave you filled with confidence. ²
Why fill with Restylane?
As we age, our skin becomes thinner and less elastic, and its ability to retain water is reduced. The result is the appearance of fine lines and wrinkles, and you may feel that you look tired, old or sad. Treatments with dermal fillers help to restore and maintain your youthful appearance and regain lost confidence.3
Restylane is a firmer dermal filler that can be used to fill wrinkles where you have good tissue coverage. Restylane Refyne is a softer and more flexible dermal filler that can be used for treatment of more dynamic areas of your face, for example, around the lips, the nasolabial folds and the marionette lines.4 Restylane and Restylane Refyne help you refine your looks and realize your individual needs and desires.
Restylane and Restylane Refyne last up to at least 18 months with one retreatment.5
Restylane and Restylane Refyne treatment areas
Restylane and Restylane Refyne are dermal fillers that are used to reduce lines and wrinkles and give you a refined and natural look. Areas that can be treated are, for example, fine lines around the mouth and eyes, marionette lines and nasolabial folds.
“And if you then all of a sudden see how signs of aging, signs of tiredness or negative expressions are erased from your face, that’s a very positive experience and usually you can see this when the patient looks in the mirror. Their face starts smiling, and that is a very rewarding moment really for an aesthetic doctor.”
Christoph Martschin, dermatologist, Sweden
Restylane and Restylane Refyne treatment areas
Restylane and Restylane Refyne are dermal fillers that are used to reduce lines and wrinkles and give you a refined and natural look. Areas that can be treated are, for example, fine lines around the mouth and eyes, marionette lines and nasolabial folds.
“And if you then all of a sudden see how signs of aging, signs of tiredness or negative expressions are erased from your face, that’s a very positive experience and usually you can see this when the patient looks in the mirror. Their face starts smiling, and that is a very rewarding moment really for an aesthetic doctor.”
Christoph Martschin, dermatologist, Sweden
Your Restylane treatment
A treatment with Restylane takes approximately 15-45 minutes, depending on the area that will be treated. Sometimes you might need a touch-up treatment about two weeks after the initial treatment to optimize your results. Most Restylane fillers contain a local anesthetic, lidocaine, that takes away most of the discomfort during treatment.
Immediately after your dermal filler treatment, you may experience some post-treatment side effects, such as redness, swelling, pain, bruising or tenderness at the treatment site. These side effects usually disappear within one week after injection. Though fillers are minimally invasive, they still carry some risks. Before the treatment, you should discuss all possible risks and benefits with your healthcare practitioner.
Restylane gives you long-lasting but non-permanent results, meaning that you can continuously refine your looks.
How it works
Hyaluronic acid is a substance that has a unique ability to bind water. Hyaluronic acid occurs naturally in our bodies and in all layers of our skin. It keeps your body tissues soft, hydrated and flexible. However, as we age, the body’s ability to produce hyaluronic acid lessens, leading to dry and thinner skin.
Native hyaluronic acid in the body degrades quickly, in one to two days. To make the hyaluronic acid in Restylane and Restylane Refyne last longer—for up to 18 months or more with one retreatment6—Galderma has used stabilization technologies that delay degradation.
Restylane contains a hyaluronic acid gel with a firmer consistency and Restylane Refyne contains a gel with a more flexible consistency to target different kinds of lines and wrinkles.
Restylane was the first ever non-animal stabilized hyaluronic acid filler, when it was launched in 1996. It has become the gold standard of dermal fillers and is the injectable filler that every other filler brand is compared with.
Before & After
- Anti-wrinkle treatments: frown lines and crow's feet;
- Dermal fillers: under eyes, cheeks, smile lines and lips.
- Individual results may vary.
- Anti-wrinkle treatments: frown and smile lines;
- Dermal fillers: cheeks and smile lines.
- Individual results may vary.
- Dermal fillers: cheeks, smile lines and jawline.
- Individual results may vary.
- Anti-wrinkle treatments: frown and smile lines;
- Dermal fillers: cheeks, smile lines and lips.
- Individual results may vary.
- Dermal fillers: under eyes.
- Individual results may vary.
- Dermal fillers: cheeks and lips.
- Individual results may vary.
- Dermal fillers: cheeks, nose, chin and lips
- Individual results may vary.
- Dermal fillers: forehead, cheekbones, cheeks, nose, lips and chin.
- Individual results may vary.
- Dermal fillers: cheekbones, nose, cheeks and smile lines
- Individual results may vary.
- Dermal fillers: cheeks, lips and chin.
- Individual results may vary.
- Dermal fillers: cheeks, smile lines and lips;
- Skin hydration boosters: cheeks
- Individual results may vary.
- Anti-wrinkle treatments: frown lines;
- Dermal fillers: under eyes, cheekbones, cheeks and smile lines.
- Individual results may vary.
- Anti-wrinkle treatments: frown lines and crow's feet;
- Dermal fillers: cheeks, smile lines, lips and chin.
- Individual results may vary.
- Anti-wrinkle treatments: frown lines and crow's feet;
- Dermal fillers: cheeks, smile lines, lips and chin.
- Individual results may vary.
- Anti-wrinkle treatments: frown lines and crow’s feet;
- Dermal fillers: cheeks and smile lines.
- Individual results may vary.
Long-lasting results – up to at least 18 months with one treatment.7
96%
of patients thought that their results looked natural8
100%
of patients saw improvement in their appearance 1 month after treatment9
FREQUENTLY ASKED QUESTIONS
How long do the effects of the treatment last?
As Restylane is a non-permanent injectable hyaluronic acid product, the effect gradually diminishes with time. In order to maintain the aesthetic result, additional treatments, or top-up treatments (see below), are recommended. Results may vary depending on the treatment area.
What is a top-up treatment?
Since Restylane filler treatments are long-lasting but not permanent, it is recommended to have top-up treatment for maintaining the results achieved in the initial treatment. Top-up treatments will most likely require lower volumes of hyaluronic acid, depending on the injection area and the time gaps between the treatments.
What should I apply or avoid after the treatment?
• Avoid applying make-up to the skin immediately after treatment.
• Light cover up may be used to conceal any remaining redness after approximately 24 hours.
• A yellow-toned concealer may be used to hide signs of bruising.
• In order to cover up any redness, a concealer with a slight green/yellow tone is recommended.
What are the possible side effects?
The most common side effects include treatment site reactions such as swelling, bruising, redness, pain and tenderness. These side effects generally disappear within one week after injection. Other potential side effects can occur with dermal filler injections. You should discuss the potential treatment risks with your healthcare practitioner.
Who manufactures Restylane filler products?
Restylane is manufactured by Galderma. Galderma is a pharmaceutical company with over 6,000 employees worldwide. The company specializes in dermatology and is present in more than 100 countries. To read more about Galderma visit About Galderma.
Skin insights
Our portfolio of products
Galderma has developed a diverse portfolio of products that work holistically together.
Refresh
Refresh your skin from within with a boost of deep hydration, for a refreshed and vibrant look that lasts.
Renew
Renew the structure of your skin with a collagen activator that gradually builds the foundation of the youthful, firmer you.
References
- Philipp-Dormston WG et al. Dermatol Surg 2018;44(6):826-832.; Weiss RA et al. Dermatol Surg 2016;42:699–709.; Narins RS et al. Dermatol Surg 2011;37:644–650.
- Talarico S et al. Dermatol Surg 2015;41:1361–1369.; Rzany B et al. Dermatol Surg 2012;38:1153–1161.
- Talarico S et al. Dermatol Surg 2015;41:1361–1369.; Rzany B et al. Dermatol Surg 2012;38:1153–1161.
- Philipp-Dormston WG et al. Dermatol Surg 2018;44(6):826-832.
- Narins RS et al. Dermatol Surg 2008;34:S2–S8.; Rzany B et al. Dermatol Surg 2017;43:58–65.
- Narins RS et al. Dermatol Surg 2008;34:S2–S8.; Rzany B et al. Dermatol Surg 2017;43:58–65.
- Rzany B et al. Dermatol Surg 2017;43:58–65.; Narins RS et al. Dermatol Surg 2008;34:S2–S8.
- Rzany B et al. Dermatol Surg 2012;38:1153–1161.
- Swift A et al. Clin Cosmet Investig Dermatol 2017;10:229–238.