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To fill lines and wrinkles, try Restylane® and Restylane® Refyne™

Restylane and Restylane Refyne are dermal fillers that provide long-lasting reduction of lines and wrinkles, such as nasolabial folds (smile lines) and marionette lines (laugh lines).¹  With Restylane and Restylane Refyne you get tailored and natural results that leave you filled with confidence. ²

Why Fill?
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Why fill with Restylane? 

As we age, our skin becomes thinner and less elastic, and its ability to retain water is reduced. The result is the appearance of fine lines and wrinkles, and you may feel that you look tired, old or sad. Treatments with dermal fillers help to restore and maintain your youthful appearance and regain lost confidence.3

Restylane is a firmer dermal filler that can be used to fill wrinkles where you have good tissue coverage. Restylane Refyne is a softer and more flexible dermal filler that can be used for treatment of more dynamic areas of your face, for example, around the lips, the nasolabial folds and the marionette lines.4  Restylane and Restylane Refyne help you refine your looks and realize your individual needs and desires.

Restylane and Restylane Refyne last up to at least 18 months with one retreatment.5

Treatment areas

Restylane and Restylane Refyne treatment areas

Restylane and Restylane Refyne are dermal fillers that are used to reduce lines and wrinkles and give you a refined and natural look. Areas that can be treated are, for example, fine lines around the mouth and eyes, marionette lines and nasolabial folds. 

“And if you then all of a sudden see how signs of aging, signs of tiredness or negative expressions are erased from your face, that’s a very positive experience and usually you can see this when the patient looks in the mirror. Their face starts smiling, and that is a very rewarding moment really for an aesthetic doctor.”

Christoph Martschin, dermatologist, Sweden

REFINE FILL Treatment Areas
NASOLABIL FOLDS
LIPS
TEAR TROUGH
MARIONETTE LINES
UPPER LIP LINES

Restylane and Restylane Refyne treatment areas

REFINE FILL Treatment Areas
TEAR TROUGH
NASOLABIL FOLDS
UPPER LIP LINES
MARIONETTE LINES
LIPS

Restylane and Restylane Refyne are dermal fillers that are used to reduce lines and wrinkles and give you a refined and natural look. Areas that can be treated are, for example, fine lines around the mouth and eyes, marionette lines and nasolabial folds. 

“And if you then all of a sudden see how signs of aging, signs of tiredness or negative expressions are erased from your face, that’s a very positive experience and usually you can see this when the patient looks in the mirror. Their face starts smiling, and that is a very rewarding moment really for an aesthetic doctor.”

Christoph Martschin, dermatologist, Sweden

Your treatment
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Your Restylane treatment

A treatment with Restylane takes approximately 15-45 minutes, depending on the area that will be treated. Sometimes you might need a touch-up treatment about two weeks after the initial treatment to optimize your results. Most Restylane fillers contain a local anesthetic, lidocaine, that takes away most of the discomfort during treatment. 

Immediately after your dermal filler treatment, you may experience some post-treatment side effects, such as redness, swelling, pain, bruising or tenderness at the treatment site. These side effects usually disappear within one week after injection. Though fillers are minimally invasive, they still carry some risks. Before the treatment, you should discuss all possible risks and benefits with your healthcare practitioner.

Restylane gives you long-lasting but non-permanent results, meaning that you can continuously refine your looks. 

How it works
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How it works

Hyaluronic acid is a substance that has a unique ability to bind water. Hyaluronic acid occurs naturally in our bodies and in all layers of our skin. It keeps your body tissues soft, hydrated and flexible. However, as we age, the body’s ability to produce hyaluronic acid lessens, leading to dry and thinner skin.  

Native hyaluronic acid in the body degrades quickly, in one to two days. To make the hyaluronic acid in Restylane and Restylane Refyne last longer—for up to 18 months or more with one retreatment6—Galderma has used stabilization technologies that delay degradation. 
Restylane contains a hyaluronic acid gel with a firmer consistency and Restylane Refyne contains a gel with a more flexible consistency to target different kinds of lines and wrinkles. 

Restylane was the first ever non-animal stabilized hyaluronic acid filler, when it was launched in 1996. It has become the gold standard of dermal fillers and is the injectable filler that every other filler brand is compared with.

Before & After

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Catherine_BEFORE
Ninorta_BEFORE
Jean-Paul_Pietrus_BEFORE
Christina_BEFORE
Vanessa_Samuels
Cassandra_Valborg_BEFORE
Irina_Sagtegen_BEFORE
Jessica_BEFORE
Shahrul_BEFORE
Sibel_Ama_BEFORE
Jenny_Sheleby_BEFORE
Kathy_Chan_BEFORE
Maria_BEFORE
Sofia_BEFORE
Yohan_Vandemberg_BEFORE
Catherine_BEFORE
Ninorta_BEFORE
Jean-Paul_Pietrus_BEFORE
Christina_BEFORE
Vanessa_Samuels
Cassandra_Valborg_BEFORE
Irina_Sagtegen_BEFORE
Jessica_BEFORE
Shahrul_BEFORE
Sibel_Ama_BEFORE
Jenny_Sheleby_BEFORE
Kathy_Chan_BEFORE
Maria_BEFORE
Sofia_BEFORE
Yohan_Vandemberg_BEFORE
Before Catherine_BEFORE
After Catherine_AFTER
Caption
  • Anti-wrinkle treatments: frown lines and crow's feet;
  • Dermal fillers: under eyes, cheeks, smile lines and lips.
  • Individual results may vary.
Before Ninorta_BEFORE
After Ninorta_AFTER
Caption
  • Anti-wrinkle treatments: frown and smile lines; 
  • Dermal fillers: cheeks and smile lines.
  • Individual results may vary.
Before Jean-Paul_Pietrus_BEFORE
After Jean-Paul_Pietrus_AFTER
Caption
  • Dermal fillers: cheeks, smile lines and jawline.
  • Individual results may vary.
Before Christina_BEFORE
After Christina_AFTER
Caption
  • Anti-wrinkle treatments: frown and smile lines; 
  • Dermal fillers: cheeks, smile lines and lips. 
  • Individual results may vary.
Before Vanessa_Samuels
After Vanessa_Samuels_AFTER
Caption
  • Dermal fillers: under eyes.
  • Individual results may vary.
Before Cassandra_Valborg_BEFORE
After Cassandra_Valborg_AFTER
Caption
  • Dermal fillers: cheeks and lips.
  • Individual results may vary.
Before Irina_Sagtegen_BEFORE
After Irina_Sagtegen_AFTER
Caption
  • Dermal fillers: cheeks, nose, chin and lips
  • Individual results may vary.
Before Jessica_BEFORE
After Jessica_AFTER
Caption
  • Dermal fillers: forehead, cheekbones, cheeks, nose, lips and chin.
  • Individual results may vary.
Before Shahrul_BEFORE
After Shahrul_AFTER
Caption
  • Dermal fillers:  cheekbones, nose, cheeks and smile lines
  • Individual results may vary.
Before Sibel_Ama_BEFORE
After Sibel_Ama_AFTER
Caption
  • Dermal fillers: cheeks, lips and chin.
  • Individual results may vary.
Before Jenny_Sheleby_BEFORE
After Jenny_Sheleby_AFTER
Caption
  • Dermal fillers: cheeks, smile lines and lips;
  • Skin hydration boosters: cheeks
  • Individual results may vary.
Before Kathy_Chan_BEFORE
After Kathy_Chan_AFTER
Caption
  • Anti-wrinkle treatments: frown lines; 
  • Dermal fillers: under eyes, cheekbones, cheeks and smile lines.
  • Individual results may vary.
Before Maria_BEFORE
After Maria_AFTER
Caption
  • Anti-wrinkle treatments: frown lines and crow's feet; 
  • Dermal fillers: cheeks, smile lines, lips and chin.
  • Individual results may vary.
Before Sofia_BEFORE
After Sofia_AFTER
Caption
  • Anti-wrinkle treatments: frown lines and crow's feet; 
  • Dermal fillers: cheeks, smile lines, lips and chin.
  • Individual results may vary.
Before Yohan_Vandemberg_BEFORE
After Yohan_Vandemberg_AFTER
Caption
  • Anti-wrinkle treatments: frown lines and crow’s feet; 
  • Dermal fillers: cheeks and smile lines.
  • Individual results may vary.

Long-lasting results – up to at least 18 months with one treatment.7

96%

of patients thought that their results looked natural8

100%

of patients saw improvement in their appearance 1 month after treatment9

FREQUENTLY ASKED QUESTIONS

You will always have a consultation before your first treatment. Think through what you want to achieve and the questions you may have. Your healthcare practitioner will inform you how Restylane fillers can be used in a safe way to suit your own individual aspirations. You will also be asked about your medical history. When you leave your consultation, you should feel well informed about Restylane fillers and you should know what results to expect.

First of all, you should always contact a qualified healthcare practitioner to be assured that your dermal filler treatment will be performed correctly. You could always search in national registers of licensed aesthetic treatment specialists. Your treatment should be performed in a medical environment that affords you privacy and is spotlessly clean. You may want to request to see your chosen practitioner’s training certificate and insurance certificate to ensure that he or she is appropriately trained and insured for the treatment.

Only a medically qualified practitioner should perform Restylane treatments. Depending on your country’s legislation, this may include plastic surgeons, cosmetic clinicians, dermatologists, cosmetic dentists, or aesthetic nurses. If in doubt, please see our list of certified clinics/practitioners close to you.  

You should receive comprehensive information and a detailed explanation regarding your Restylane filler treatment.

•    You should be informed of the possibilities and limitations of treatments with hyaluronic acid.
•    You should receive information about possible side effects and precautions for treatment.
•    You should be informed of the cost of the treatment and possible follow-up treatments.
•    Your questions should be answered to your full satisfaction.

There are several important precautions to discuss with your healthcare practitioner to ensure satisfactory results and avoid any complications. Discuss the following with your healthcare practitioner:
•    If you are taking immunosuppressive medications
•    If you are taking aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) or any other medication that affects bleeding
•    If you have any questions about precautions related to the treatment

First, the healthcare practitioner disinfects the area to be treated. A small amount of the appropriate Restylane filler is then injected into the skin through a fine needle or blunt micro-cannula to fill wrinkles, add volume, shape your face or fill your lips. After the injection, your practitioner may gently massage the treated area to even out the result.

Skin insights

Our portfolio of products

Galderma has developed a diverse portfolio of products that work holistically together.

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Refresh

Refresh your skin from within with a boost of deep hydration, for a refreshed and vibrant look that lasts.

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Renew

Renew the structure of your skin with a collagen activator that gradually builds the foundation of the youthful, firmer you.

References

  1. Philipp-Dormston WG et al. Dermatol Surg 2018;44(6):826-832.; Weiss RA et al. Dermatol Surg 2016;42:699–709.; Narins RS et al. Dermatol Surg 2011;37:644–650.
  2. Talarico S et al. Dermatol Surg 2015;41:1361–1369.; Rzany B et al. Dermatol Surg 2012;38:1153–1161.
  3. Talarico S et al. Dermatol Surg 2015;41:1361–1369.; Rzany B et al. Dermatol Surg 2012;38:1153–1161.
  4. Philipp-Dormston WG et al. Dermatol Surg 2018;44(6):826-832.
  5. Narins RS et al. Dermatol Surg 2008;34:S2–S8.; Rzany B et al. Dermatol Surg 2017;43:58–65.
  6. Narins RS et al. Dermatol Surg 2008;34:S2–S8.; Rzany B et al. Dermatol Surg 2017;43:58–65.
  7. Rzany B et al. Dermatol Surg 2017;43:58–65.; Narins RS et al. Dermatol Surg 2008;34:S2–S8.
  8. Rzany B et al. Dermatol Surg 2012;38:1153–1161.
  9. Swift A et al. Clin Cosmet Investig Dermatol 2017;10:229–238.